@article{130036,
  keywords = {Animals, Glutamic Acid, Mice, Neuronal Plasticity, Interneurons, Conditioning (Psychology), Cholinergic Neurons, Cocaine, Extinction, Psychological, Food, Nucleus Accumbens, Reinforcement (Psychology)},
  author = {Junuk Lee and Joel Finkelstein and Jung Yoon Choi and Ilana Witten},
  title = {Linking Cholinergic Interneurons, Synaptic Plasticity, and Behavior during the Extinction of a Cocaine-Context Association},
  abstract = { Despite the fact that cholinergic interneurons are a key cell type within the nucleus accumbens, a relationship between synaptic plasticity and the in~vivo activity of cholinergic interneurons remains to be established. Here, we identify a three-way link between the activity of cholinergic interneurons, synaptic plasticity, and learning in mice undergoing the extinction of a cocaine-context association. We found that activity of cholinergic interneurons regulates extinction learning for a cocaine-context association and generates a sustained reduction in glutamatergic presynaptic strength onto medium spiny neurons. Interestingly, activation of cholinergic interneurons does not support reinforcement learning or plasticity by itself, suggesting that these neurons have a modulatory rather than a reinforcing function. },
  year = {2016},
  journal = {Neuron},
  volume = {90},
  pages = {1071-1085},
  month = {06/2016},
  issn = {1097-4199},
  doi = {10.1016/j.neuron.2016.05.001},
  language = {eng},
}